?????? ?????? ??????? ?????? ?????? ??????? ????? ??????????? ????? ???? ????? ????? ?????? ???? ???? ??????? ?????In people with creatinine clearance charges a lot less than 50 mL/min, begin OPANA ER while in the opioid-naïve client While using the 5 mg dose. For sufferers on prior opioid therapy, start out OPANA ER at fifty% lessen compared to